Highlighted Publications
Frumkin I*#, Vassallo C*# & Laub M#
Emergence of antiphage functions from random sequence libraries reveals mechanisms of gene birth
PNAS, 2025
Frumkin I, et al., & Pilpel Y
Codon usage of highly expressed genes affects proteome-wide translation efficiency
PNAS, 2018
Frumkin I & Laub M.
Selection of a de novo gene that can promote survival of E. coli by modulating protein homeostasis pathways
Nature Ecology and Evolution, 2023
Frumkin I*, Schirman D*, et al., & Pilpel Y
Gene architectures that minimize cost of gene expression
Molecular Cell, 2017
Frumkin I#, et al., & Pilpel Y#
Evolution of intron splicing towards optimized gene expression is based on various cis and trans molecular mechanisms
PLOS Biology, 2019
Yona AH*, Bloom Z*, Frumkin I*, et al., & Pilpel Y
tRNA genes rapidly change in evolution to meet novel translational demands
eLife, 2013
All Publications
Frumkin I*#, Vassallo C*#, Chen Y & Laub M#.
Emergence of antiphage functions from random sequence libraries reveals
mechanisms of gene birth
PNAS, 2025
​
Frumkin I and Laub M.
Selection of a de novo gene that can promote survival of E. coli by modulating
protein homeostasis pathways
Nature Ecology and Evolution, 2023
​ -- News & Views - Nature Ecology and Evolution, November 2023
​
Aharon-Hefetz N, Frumkin I, Mayshar Y, Dahan O, Pilpel Y & Rak R.
Manipulation of the human tRNA pool reveals distinct tRNA sets that act in
cellular proliferation or cell cycle arrest
eLife, 2020
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Frumkin I #, Yofe I, Bar-Ziv R, Gurvich Y, Lu Y, Voichek Y, Schirman D, Krebber H & Pilpel P #
Evolution of intron splicing towards optimized gene expression is based on
various cis and trans molecular mechanisms
PLOS Biology, 2019
​
Frumkin I, Lajoie JM, Gregg JC, Hornung G, Church MG & Pilpel Y
Codon usage of highly expressed genes affects proteome-wide translation efficiency
PNAS, 2018
Frumkin I*, Schirman D*, Rotman A*, Li F, Zahavi L, Mordret E, Asraf O, Wu S, Levy S & Pilpel Y
Gene architectures that minimize cost of gene expression
Molecular Cell, 2017
​ -- Preview - Cell Systems, January 2017
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Bar-Yaacov D, Frumkin I, Yashiro Y, Chujo T, Chemla Y, Blumberg A, Orr Schlesinger, Bieri P, Greber B, Ban N, Zarivach R, Alfonta L, Pilpel Y, Suzuki T and Mishmar D
Mitochondrial 16S rRNA is methylated by tRNA methyltransferase TRMT61B in all vertebrates
PLoS Biology, 2016
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Yona AH, Frumkin I & Pilpel Y
A relay race on the evolutionary adaptation spectrum
Cell, 2015
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Avci D, Fuchs S, Schrul B, Fukumori A, Breker M, Frumkin I, Chen CY, Schilling O, Steiner H, Schuldiner M & Lemberg MK
The yeast ER protease Ypf1 refines nutrient sensing by regulating transporter abundance
Molecular Cell, 2014
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Yona AH*, Bloom-Ackerman Z*, Frumkin I*, Hanson-Smith V, Charpak-Amikam Y, Feng Q, Boeke JD, Dahan O & Pilpel Y
tRNA genes rapidly change in evolution to meet novel translational demands
eLife, 2013
-- Research Highlight - Nature Reviews Genetics, January 2014
-- Podcast - eLife, December 2013
-- Faculty of 1000 Recommended
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Krumpe K*, Frumkin I*, Herzig Y, Rimon N, Özbalci C, Brugger B, Rapaport D & Schuldiner M
Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes
Molecular Biology of the Cell, 2012
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